DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systemic lupus erythematosus. The EFO term systemic lupus erythematosus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: systemic lupus erythematosus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RR Graham, C Cotsapas, L Davies, R Hackett, CJ Lessard, JM Leon, NP Burtt, C Guiducci, M Parkin, C Gates, RM Plenge, TW Behrens, JE Wither, JD Rioux, PR Fortin, DC Graham, AK Wong, TJ Vyse, MJ Daly, D Altshuler, KL Moser, PM Gaffney

TITLE:

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

JOURNAL:

Nature genetics Sep 2008, Vol 40, pp. 1059-61

ABSTRACT:

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA. PUBMED: 19165918
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