DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting plasma glucose. The EFO term fasting blood glucose measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: fasting blood glucose measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JY Hwang, X Sim, Y Wu, J Liang, Y Tabara, C Hu, K Hara, CH Tam, Q Cai, Q Zhao, S Jee, F Takeuchi, MJ Go, RT Ong, T Ohkubo, YJ Kim, R Zhang, T Yamauchi, WY So, J Long, D Gu, NR Lee, S Kim, T Katsuya, JH Oh, J Liu, S Umemura, YJ Kim, F Jiang, S Maeda, JC Chan, W Lu, JE Hixson, LS Adair, KJ Jung, T Nabika, JB Bae, MH Lee, M Seielstad, TL Young, YY Teo, Y Kita, N Takashima, H Osawa, SH Lee, MH Shin, DH Shin, BY Choi, J Shi, YT Gao, YB Xiang, W Zheng, N Kato, M Yoon, J He, XO Shu, RC Ma, T Kadowaki, W Jia, T Miki, L Qi, ES Tai, KL Mohlke, BG Han, YS Cho, BJ Kim

TITLE:

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

JOURNAL:

Diabetes Jan 2015, Vol 64, pp. 291-8

ABSTRACT:

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation. PUBMED: 25187374
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