DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid). The EFO term omega-6 polyunsaturated fatty acid measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: omega-6 polyunsaturated fatty acid measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

W Guan, BT Steffen, RN Lemaitre, JH Wu, T Tanaka, A Manichaikul, M Foy, SS Rich, L Wang, JA Nettleton, W Tang, X Gu, S Bandinelli, IB King, B McKnight, BM Psaty, D Siscovick, L Djousse, YD Ida Chen, L Ferrucci, M Fornage, D Mozafarrian, MY Tsai, LM Steffen

TITLE:

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

JOURNAL:

Circulation. Cardiovascular genetics Jun 2014, Vol 7, pp. 321-31

ABSTRACT:

Omega6 (n6) polyunsaturated fatty acids (PUFAs) and their metabolites are involved in cell signaling, inflammation, clot formation, and other crucial biological processes. Genetic components, such as variants of fatty acid desaturase (FADS) genes, determine the composition of n6 PUFAs. PUBMED: 24823311
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