DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Pre bronchodilator FEV1/FVC ratio in never-smokers. The EFO term smoking status measurement, FEV/FEC ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: smoking status measurement, FEV/FEC ratio

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DA van der Plaat, K de Jong, L Lahousse, A Faiz, JM Vonk, CC van Diemen, I Nedeljkovic, N Amin, GG Brusselle, A Hofman, CA Brandsma, Y Bossé, DD Sin, DC Nickle, CM van Duijn, DS Postma, HM Boezen

TITLE:

Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A.

JOURNAL:

The Journal of allergy and clinical immunology Feb 2017, Vol 139, pp. 533-540

ABSTRACT:

Although a striking proportion (25% to 45%) of patients with chronic obstructive pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this group exclusively. PUBMED: 27612410
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