DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Follicular lymphoma. The EFO term neoplasm of mature B-cells was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: neoplasm of mature B-cells

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

CF Skibola, SI Berndt, J Vijai, L Conde, Z Wang, M Yeager, PI de Bakker, BM Birmann, CM Vajdic, JN Foo, PM Bracci, RC Vermeulen, SL Slager, S de Sanjose, SS Wang, MS Linet, G Salles, Q Lan, G Severi, H Hjalgrim, T Lightfoot, M Melbye, J Gu, H Ghesquières, BK Link, LM Morton, EA Holly, A Smith, LF Tinker, LR Teras, A Kricker, N Becker, MP Purdue, JJ Spinelli, Y Zhang, GG Giles, P Vineis, A Monnereau, KA Bertrand, D Albanes, A Zeleniuch-Jacquotte, A Gabbas, CC Chung, L Burdett, A Hutchinson, C Lawrence, R Montalvan, L Liang, J Huang, B Ma, J Liu, HO Adami, B Glimelius, Y Ye, GS Nowakowski, A Dogan, CA Thompson, TM Habermann, AJ Novak, M Liebow, TE Witzig, GJ Weiner, M Schenk, P Hartge, AJ De Roos, W Cozen, D Zhi, NK Akers, J Riby, MT Smith, M Lacher, DJ Villano, A Maria, E Roman, E Kane, RD Jackson, KE North, WR Diver, J Turner, BK Armstrong, Y Benavente, P Boffetta, P Brennan, L Foretova, M Maynadie, A Staines, J McKay, AR Brooks-Wilson, T Zheng, TR Holford, S Chamosa, R Kaaks, RS Kelly, B Ohlsson, RC Travis, E Weiderpass, J Clavel, E Giovannucci, P Kraft, J Virtamo, P Mazza, P Cocco, MG Ennas, BC Chiu, JF Fraumeni, A Nieters, K Offit, X Wu, JR Cerhan, KE Smedby, SJ Chanock, N Rothman

TITLE:

Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.

JOURNAL:

American journal of human genetics Oct 2014, Vol 95, pp. 462-71

ABSTRACT:

Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR(per-allele)] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (OR(per-allele) = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. PUBMED: 25279986
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