DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Alcohol dependence (age at onset). The EFO term age at onset, alcohol dependence was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: age at onset, alcohol dependence

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Kapoor, JC Wang, L Wetherill, N Le, S Bertelsen, AL Hinrichs, J Budde, A Agrawal, L Almasy, K Bucholz, DM Dick, O Harari, X Xiaoling, V Hesselbrock, J Kramer, JI Nurnberger, J Rice, M Schuckit, J Tischfield, B Porjesz, HJ Edenberg, L Bierut, T Foroud, A Goate

TITLE:

Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.

JOURNAL:

Drug and alcohol dependence Sep 2014, Vol 142, pp. 56-62

ABSTRACT:

The age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high-risk families from the Collaborative Study on the Genetics of Alcoholism (COGA). PUBMED: 24962325
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