DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Coronary heart disease. The EFO term coronary heart disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coronary heart disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DA Trégouët, IR König, J Erdmann, A Munteanu, PS Braund, AS Hall, A Grosshennig, P Linsel-Nitschke, C Perret, M DeSuremain, T Meitinger, BJ Wright, M Preuss, AJ Balmforth, SG Ball, C Meisinger, C Germain, A Evans, D Arveiler, G Luc, JB Ruidavets, C Morrison, P van der Harst, S Schreiber, K Neureuther, A Schäfer, P Bugert, NE El Mokhtari, J Schrezenmeir, K Stark, D Rubin, HE Wichmann, C Hengstenberg, W Ouwehand, A Ziegler, L Tiret, JR Thompson, F Cambien, H Schunkert, NJ Samani

TITLE:

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

JOURNAL:

Nature genetics Mar 2009, Vol 41, pp. 283-5

ABSTRACT:

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits. PUBMED: 19198611
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