GeneSet Information

Tier I GS270242 • GWAS Catalog Data for adiponectin measurement in 29,347 European ancestry individuals, 4,232 African American individuals, 1,776 Filipino ancestry individuals

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Adiponectin levels. The EFO term adiponectin measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: adiponectin measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Z Dastani, MF Hivert, N Timpson, JR Perry, X Yuan, RA Scott, P Henneman, IM Heid, JR Kizer, LP Lyytikäinen, C Fuchsberger, T Tanaka, AP Morris, K Small, A Isaacs, M Beekman, S Coassin, K Lohman, L Qi, S Kanoni, JS Pankow, HW Uh, Y Wu, A Bidulescu, LJ Rasmussen-Torvik, CM Greenwood, M Ladouceur, J Grimsby, AK Manning, CT Liu, J Kooner, VE Mooser, P Vollenweider, KA Kapur, J Chambers, NJ Wareham, C Langenberg, R Frants, K Willems-Vandijk, BA Oostra, SM Willems, C Lamina, TW Winkler, BM Psaty, RP Tracy, J Brody, I Chen, J Viikari, M Kähönen, PP Pramstaller, DM Evans, B St Pourcain, N Sattar, AR Wood, S Bandinelli, OD Carlson, JM Egan, S Böhringer, D van Heemst, L Kedenko, K Kristiansson, ML Nuotio, BM Loo, T Harris, M Garcia, A Kanaya, M Haun, N Klopp, HE Wichmann, P Deloukas, E Katsareli, DJ Couper, BB Duncan, M Kloppenburg, LS Adair, JB Borja, JG Wilson, S Musani, X Guo, T Johnson, R Semple, TM Teslovich, MA Allison, S Redline, SG Buxbaum, KL Mohlke, I Meulenbelt, CM Ballantyne, GV Dedoussis, FB Hu, Y Liu, B Paulweber, TD Spector, PE Slagboom, L Ferrucci, A Jula, M Perola, O Raitakari, JC Florez, V Salomaa, JG Eriksson, TM Frayling, AA Hicks, T Lehtimäki, GD Smith, DS Siscovick, F Kronenberg, C van Duijn, RJ Loos, DM Waterworth, JB Meigs, J Dupuis, JB Richards, BF Voight, LJ Scott, V Steinthorsdottir, C Dina, RP Welch, E Zeggini, C Huth, YS Aulchenko, G Thorleifsson, LJ McCulloch, T Ferreira, H Grallert, N Amin, G Wu, CJ Willer, S Raychaudhuri, SA McCarroll, OM Hofmann, AV Segrè, M van Hoek, P Navarro, K Ardlie, B Balkau, R Benediktsson, AJ Bennett, R Blagieva, E Boerwinkle, LL Bonnycastle, KB Boström, B Bravenboer, S Bumpstead, NP Burtt, G Charpentier, PS Chines, M Cornelis, G Crawford, AS Doney, KS Elliott, AL Elliott, MR Erdos, CS Fox, CS Franklin, M Ganser, C Gieger, N Grarup, T Green, S Griffin, CJ Groves, C Guiducci, S Hadjadj, N Hassanali, C Herder, B Isomaa, AU Jackson, PR Johnson, T Jørgensen, WH Kao, A Kong, P Kraft, J Kuusisto, T Lauritzen, M Li, A Lieverse, CM Lindgren, V Lyssenko, M Marre, T Meitinger, K Midthjell, MA Morken, N Narisu, P Nilsson, KR Owen, F Payne, AK Petersen, C Platou, C Proença, I Prokopenko, W Rathmann, NW Rayner, NR Robertson, G Rocheleau, M Roden, MJ Sampson, R Saxena, BM Shields, P Shrader, G Sigurdsson, T Sparsø, K Strassburger, HM Stringham, Q Sun, AJ Swift, B Thorand, J Tichet, T Tuomi, RM van Dam, TW van Haeften, T van Herpt, JV van Vliet-Ostaptchouk, GB Walters, MN Weedon, C Wijmenga, J Witteman, RN Bergman, S Cauchi, FS Collins, AL Gloyn, U Gyllensten, T Hansen, WA Hide, GA Hitman, A Hofman, DJ Hunter, K Hveem, M Laakso, AD Morris, CN Palmer, I Rudan, E Sijbrands, LD Stein, J Tuomilehto, A Uitterlinden, M Walker, RM Watanabe, GR Abecasis, BO Boehm, H Campbell, MJ Daly, AT Hattersley, O Pedersen, I Barroso, L Groop, R Sladek, U Thorsteinsdottir, JF Wilson, T Illig, P Froguel, CM van Duijn, K Stefansson, D Altshuler, M Boehnke, MI McCarthy, N Soranzo, E Wheeler, NL Glazer, N Bouatia-Naji, R Mägi, J Randall, P Elliott, D Rybin, A Dehghan, JJ Hottenga, K Song, A Goel, T Lajunen, A Doney, C Cavalcanti-Proença, M Kumari, NJ Timpson, C Zabena, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, RM Roccasecca, F Pattou, P Sethupathy, Y Ariyurek, P Barter, JP Beilby, Y Ben-Shlomo, S Bergmann, M Bochud, A Bonnefond, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, L Crisponi, IN Day, EJ de Geus, J Delplanque, AC Fedson, A Fischer-Rosinsky, NG Forouhi, MG Franzosi, P Galan, MO Goodarzi, J Graessler, S Grundy, R Gwilliam, G Hallmans, N Hammond, X Han, AL Hartikainen, C Hayward, SC Heath, S Hercberg, DR Hillman, AD Hingorani, J Hui, J Hung, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, R Mahley, M Mangino, MT Martínez-Larrad, JB McAteer, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, S Mukherjee, S Naitza, MJ Neville, M Orrù, R Pakyz, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, NW Rayner, K Rice, S Ripatti, F Rivadeneira, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, U Seedorf, SJ Sharp, B Shields, G Sigurðsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, A Tönjes, AG Uitterlinden, KW van Dijk, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, KL Ward, H Watkins, SH Wild, G Willemsen, JC Witteman, JW Yarnell, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, P Meneton, PK Magnusson, DM Nathan, GH Williams, K Silander, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, M Serrano-Ríos, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, PP Pramstaller, AF Wright, M Stumvoll, A Hamsten, TA Buchanan, TT Valle, JI Rotter, BW Penninx, DI Boomsma, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, L Peltonen, V Mooser, R Sladek, K Musunuru, AV Smith, AC Edmondson, IM Stylianou, M Koseki, JP Pirruccello, DI Chasman, CT Johansen, SW Fouchier, GM Peloso, M Barbalic, SL Ricketts, JC Bis, MF Feitosa, M Orho-Melander, O Melander, X Li, M Li, YS Cho, MJ Go, YJ Kim, JY Lee, T Park, K Kim, X Sim, RT Ong, DC Croteau-Chonka, LA Lange, JD Smith, A Ziegler, W Zhang, RY Zee, JB Whitfield, JR Thompson, I Surakka, TD Spector, JH Smit, J Sinisalo, J Scott, J Saharinen, C Sabatti, LM Rose, R Roberts, M Rieder, AN Parker, G Pare, CJ O'Donnell, MS Nieminen, DA Nickerson, GW Montgomery, W McArdle, D Masson, NG Martin, F Marroni, G Lucas, R Luben, ML Lokki, G Lettre, LJ Launer, EG Lakatta, R Laaksonen, KO Kyvik, IR König, KT Khaw, LM Kaplan, Å Johansson, AC Janssens, W Igl, GK Hovingh, C Hengstenberg, AS Havulinna, ND Hastie, TB Harris, T Haritunians, AS Hall, LC Groop, E Gonzalez, NB Freimer, J Erdmann, KG Ejebe, A Döring, AF Dominiczak, S Demissie, P Deloukas, U de Faire, G Crawford, YD Chen, MJ Caulfield, SM Boekholdt, TL Assimes, T Quertermous, M Seielstad, TY Wong, ES Tai, AB Feranil, CW Kuzawa, HA Taylor, SB Gabriel, H Holm, V Gudnason, RM Krauss, JM Ordovas, PB Munroe, JS Kooner, AR Tall, RA Hegele, JJ Kastelein, EE Schadt, DP Strachan, MP Reilly, NJ Samani, H Schunkert, LA Cupples, MS Sandhu, PM Ridker, DJ Rader, S Kathiresan

TITLE:

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

JOURNAL:

PLoS genetics None 2012, Vol 8, pp. e1002607

ABSTRACT:

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance. PUBMED: 22479202
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adiponectin measurement (EFO:0004502)

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