DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cold medicine related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS-TEN) with severe mucosal involvement. The EFO term Stevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Stevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Ueta, H Sawai, C Sotozono, Y Hitomi, N Kaniwa, MK Kim, KY Seo, KC Yoon, CK Joo, C Kannabiran, TH Wakamatsu, V Sangwan, V Rathi, S Basu, T Ozeki, T Mushiroda, E Sugiyama, K Maekawa, R Nakamura, M Aihara, K Matsunaga, A Sekine, JÁ Gomes, J Hamuro, Y Saito, M Kubo, S Kinoshita, K Tokunaga

TITLE:

IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement.

JOURNAL:

The Journal of allergy and clinical immunology Jun 2015, Vol 135, pp. 1538-45.e17

ABSTRACT:

Stevens-Johnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface, oral cavity, and genitals. These reactions are very rare but are often associated with inciting drugs, infectious agents, or both. PUBMED: 25672763
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