DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting plasma glucose. The EFO term fasting blood glucose measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: fasting blood glucose measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

N Bouatia-Naji, A Bonnefond, C Cavalcanti-Proença, T Sparsø, J Holmkvist, M Marchand, J Delplanque, S Lobbens, G Rocheleau, E Durand, F De Graeve, JC Chèvre, K Borch-Johnsen, AL Hartikainen, A Ruokonen, J Tichet, M Marre, J Weill, B Heude, M Tauber, K Lemaire, F Schuit, P Elliott, T Jørgensen, G Charpentier, S Hadjadj, S Cauchi, M Vaxillaire, R Sladek, S Visvikis-Siest, B Balkau, C Lévy-Marchal, F Pattou, D Meyre, AI Blakemore, MR Jarvelin, AJ Walley, T Hansen, C Dina, O Pedersen, P Froguel

TITLE:

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.

JOURNAL:

Nature genetics Jan 2009, Vol 41, pp. 89-94

ABSTRACT:

In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway. PUBMED: 19060909
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