DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting plasma glucose. The EFO term fasting blood glucose measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: fasting blood glucose measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

I Prokopenko, C Langenberg, JC Florez, R Saxena, N Soranzo, G Thorleifsson, RJ Loos, AK Manning, AU Jackson, Y Aulchenko, SC Potter, MR Erdos, S Sanna, JJ Hottenga, E Wheeler, M Kaakinen, V Lyssenko, WM Chen, K Ahmadi, JS Beckmann, RN Bergman, M Bochud, LL Bonnycastle, TA Buchanan, A Cao, A Cervino, L Coin, FS Collins, L Crisponi, EJ de Geus, A Dehghan, P Deloukas, AS Doney, P Elliott, N Freimer, V Gateva, C Herder, A Hofman, TE Hughes, S Hunt, T Illig, M Inouye, B Isomaa, T Johnson, A Kong, M Krestyaninova, J Kuusisto, M Laakso, N Lim, U Lindblad, CM Lindgren, OT McCann, KL Mohlke, AD Morris, S Naitza, M Orrù, CN Palmer, A Pouta, J Randall, W Rathmann, J Saramies, P Scheet, LJ Scott, A Scuteri, S Sharp, E Sijbrands, JH Smit, K Song, V Steinthorsdottir, HM Stringham, T Tuomi, J Tuomilehto, AG Uitterlinden, BF Voight, D Waterworth, HE Wichmann, G Willemsen, JC Witteman, X Yuan, JH Zhao, E Zeggini, D Schlessinger, M Sandhu, DI Boomsma, M Uda, TD Spector, BW Penninx, D Altshuler, P Vollenweider, MR Jarvelin, E Lakatta, G Waeber, CS Fox, L Peltonen, LC Groop, V Mooser, LA Cupples, U Thorsteinsdottir, M Boehnke, I Barroso, C Van Duijn, J Dupuis, RM Watanabe, K Stefansson, MI McCarthy, NJ Wareham, JB Meigs, GR Abecasis

TITLE:

Variants in MTNR1B influence fasting glucose levels.

JOURNAL:

Nature genetics Jan 2009, Vol 41, pp. 77-81

ABSTRACT:

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci. PUBMED: 19060907
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