DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Menarche (age at onset). The EFO term age at menarche was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: age at menarche

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JR Perry, L Stolk, N Franceschini, KL Lunetta, G Zhai, PF McArdle, AV Smith, T Aspelund, S Bandinelli, E Boerwinkle, L Cherkas, G Eiriksdottir, K Estrada, L Ferrucci, AR Folsom, M Garcia, V Gudnason, A Hofman, D Karasik, DP Kiel, LJ Launer, J van Meurs, MA Nalls, F Rivadeneira, AR Shuldiner, A Singleton, N Soranzo, T Tanaka, JA Visser, MN Weedon, SG Wilson, V Zhuang, EA Streeten, TB Harris, A Murray, TD Spector, EW Demerath, AG Uitterlinden, JM Murabito

TITLE:

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

JOURNAL:

Nature genetics Jun 2009, Vol 41, pp. 648-50

ABSTRACT:

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation. PUBMED: 19448620
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