DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Menarche (age at onset). The EFO term age at menarche was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: age at menarche

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

P Sulem, DF Gudbjartsson, T Rafnar, H Holm, EJ Olafsdottir, GH Olafsdottir, T Jonsson, P Alexandersen, B Feenstra, HA Boyd, KK Aben, AL Verbeek, N Roeleveld, A Jonasdottir, U Styrkarsdottir, V Steinthorsdottir, A Karason, SN Stacey, J Gudmundsson, M Jakobsdottir, G Thorleifsson, G Hardarson, J Gulcher, A Kong, LA Kiemeney, M Melbye, C Christiansen, L Tryggvadottir, U Thorsteinsdottir, K Stefansson

TITLE:

Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.

JOURNAL:

Nature genetics Jun 2009, Vol 41, pp. 734-8

ABSTRACT:

Earlier menarche correlates with shorter adult height and higher childhood body fat. We conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women. Combined analysis with replication sets from Iceland, Denmark and the Netherlands (N = 10,040) yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM (effect = 1.2 months later per allele; P = 1.8 × 10(-14)). A second SNP within the same linkage disequilibrium (LD) block, rs314277, splits rs314280[T] into two haplotypes with different effects (0.9 months and 1.9 months per allele). These variants have been associated with greater adult height. The association with adult height did not account for the association with AAM or vice versa. Other variants, previously associated with height, did not associate significantly with AAM. Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM. PUBMED: 19448622
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