DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Venous thromboembolism (SNP x SNP interaction). The EFO term venous thromboembolism was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: venous thromboembolism

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

N Greliche, M Germain, JC Lambert, W Cohen, M Bertrand, AM Dupuis, L Letenneur, M Lathrop, P Amouyel, PE Morange, DA Trégouët

TITLE:

A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.

JOURNAL:

BMC medical genetics Mar 2013, Vol 14, pp. 36

ABSTRACT:

Venous Thrombosis (VT) is a common multifactorial disease with an estimated heritability between 35% and 60%. Known genetic polymorphisms identified so far only explain ~5% of the genetic variance of the disease. This study was aimed to investigate whether pair-wise interactions between common single nucleotide polymorphisms (SNPs) could exist and modulate the risk of VT. PUBMED: 23509962
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