GeneSet Information

Tier I GS270130 • GWAS Catalog Data for lung carcinoma in up to 14,900 European ancestry cases, up to 29,485 European ancestry controls

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Lung cancer. The EFO term lung carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: lung carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

MN Timofeeva, RJ Hung, T Rafnar, DC Christiani, JK Field, H Bickeböller, A Risch, JD McKay, Y Wang, J Dai, V Gaborieau, J McLaughlin, D Brenner, SA Narod, NE Caporaso, D Albanes, M Thun, T Eisen, HE Wichmann, A Rosenberger, Y Han, W Chen, D Zhu, M Spitz, X Wu, M Pande, Y Zhao, D Zaridze, N Szeszenia-Dabrowska, J Lissowska, P Rudnai, E Fabianova, D Mates, V Bencko, L Foretova, V Janout, HE Krokan, ME Gabrielsen, F Skorpen, L Vatten, I Njølstad, C Chen, G Goodman, M Lathrop, S Benhamou, T Vooder, K Välk, M Nelis, A Metspalu, O Raji, Y Chen, J Gosney, T Liloglou, T Muley, H Dienemann, G Thorleifsson, H Shen, K Stefansson, P Brennan, CI Amos, R Houlston, MT Landi

TITLE:

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

JOURNAL:

Human molecular genetics Nov 2012, Vol 21, pp. 4980-95

ABSTRACT:

Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21-6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P = 7.2 × 10(-16)), 6p21 (P = 2.3 × 10(-14)) and 15q25 (P = 2.2 × 10(-63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P = 3.0 × 10(-7)) which was replicated in a series of 5415 Han Chinese (P = 0.03; combined analysis, P = 2.3 × 10(-8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer. PUBMED: 22899653
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lung carcinoma (EFO:0001071)

Gene List • 1 Genes

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