DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Pancreatic cancer. The EFO term pancreatic carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: pancreatic carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

L Amundadottir, P Kraft, RZ Stolzenberg-Solomon, CS Fuchs, GM Petersen, AA Arslan, HB Bueno-de-Mesquita, M Gross, K Helzlsouer, EJ Jacobs, A LaCroix, W Zheng, D Albanes, W Bamlet, CD Berg, F Berrino, S Bingham, JE Buring, PM Bracci, F Canzian, F Clavel-Chapelon, S Clipp, M Cotterchio, M de Andrade, EJ Duell, JW Fox, S Gallinger, JM Gaziano, EL Giovannucci, M Goggins, CA González, G Hallmans, SE Hankinson, M Hassan, EA Holly, DJ Hunter, A Hutchinson, R Jackson, KB Jacobs, M Jenab, R Kaaks, AP Klein, C Kooperberg, RC Kurtz, D Li, SM Lynch, M Mandelson, RR McWilliams, JB Mendelsohn, DS Michaud, SH Olson, K Overvad, AV Patel, PH Peeters, A Rajkovic, E Riboli, HA Risch, XO Shu, G Thomas, GS Tobias, D Trichopoulos, SK Van Den Eeden, J Virtamo, J Wactawski-Wende, BM Wolpin, H Yu, K Yu, A Zeleniuch-Jacquotte, SJ Chanock, P Hartge, RN Hoover

TITLE:

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

JOURNAL:

Nature genetics Sep 2009, Vol 41, pp. 986-90

ABSTRACT:

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B. PUBMED: 19648918
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