DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Intraocular pressure. The EFO term intraocular pressure measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: intraocular pressure measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

PG Hysi, CY Cheng, H Springelkamp, S Macgregor, JN Bailey, R Wojciechowski, V Vitart, A Nag, AW Hewitt, R Höhn, C Venturini, A Mirshahi, WD Ramdas, G Thorleifsson, E Vithana, CC Khor, AB Stefansson, J Liao, JL Haines, N Amin, YX Wang, PS Wild, AB Ozel, JZ Li, BW Fleck, T Zeller, SE Staffieri, YY Teo, G Cuellar-Partida, X Luo, RR Allingham, JE Richards, A Senft, LC Karssen, Y Zheng, C Bellenguez, L Xu, AI Iglesias, JF Wilson, JH Kang, EM van Leeuwen, V Jonsson, U Thorsteinsdottir, DD Despriet, S Ennis, SE Moroi, NG Martin, NM Jansonius, S Yazar, ES Tai, P Amouyel, J Kirwan, LM van Koolwijk, MA Hauser, F Jonasson, P Leo, SJ Loomis, R Fogarty, F Rivadeneira, L Kearns, KJ Lackner, PT de Jong, CL Simpson, CE Pennell, BA Oostra, AG Uitterlinden, SM Saw, AJ Lotery, JE Bailey-Wilson, A Hofman, JR Vingerling, C Maubaret, N Pfeiffer, RC Wolfs, HG Lemij, TL Young, LR Pasquale, C Delcourt, TD Spector, CC Klaver, KS Small, KP Burdon, K Stefansson, TY Wong, A Viswanathan, DA Mackey, JE Craig, JL Wiggs, CM van Duijn, CJ Hammond, T Aung

TITLE:

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.

JOURNAL:

Nature genetics Oct 2014, Vol 46, pp. 1126-30

ABSTRACT:

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG. PUBMED: 25173106
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