DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Trans fatty acid levels. The EFO term trans fatty acid measurement, trans-16:1n-7 fatty acid measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: trans fatty acid measurement, trans-16:1n-7 fatty acid measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

D Mozaffarian, EK Kabagambe, CO Johnson, RN Lemaitre, A Manichaikul, Q Sun, M Foy, L Wang, H Wiener, MR Irvin, SS Rich, H Wu, MK Jensen, DI Chasman, AY Chu, M Fornage, L Steffen, IB King, B McKnight, BM Psaty, L Djoussé, IY Chen, JH Wu, DS Siscovick, PM Ridker, MY Tsai, EB Rimm, FB Hu, DK Arnett

TITLE:

Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

JOURNAL:

The American journal of clinical nutrition Feb 2015, Vol 101, pp. 398-406

ABSTRACT:

Circulating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent influences (e.g., relating to incorporation, metabolism, or intercompetition with other fatty acids) that could alter circulating concentrations and possibly modulate or mediate impacts on health. PUBMED: 25646338
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