DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Aggressive periodontitis (sex interaction). The EFO term aggressive periodontitis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: aggressive periodontitis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

S Freitag-Wolf, H Dommisch, C Graetz, Y Jockel-Schneider, I Harks, I Staufenbiel, J Meyle, P Eickholz, B Noack, C Bruckmann, C Gieger, S Jepsen, W Lieb, S Schreiber, IR König, AS Schaefer

TITLE:

Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.

JOURNAL:

Journal of clinical periodontology Dec 2014, Vol 41, pp. 1115-21

ABSTRACT:

Periodontitis (PD) is influenced by genetic as well as lifestyle and socio-economic factors. Epidemiological studies show that men are at greater risk of severe forms of PD, suggesting interplay between sex and genetic factors. We aimed to systematically analyse patients with aggressive periodontitis (AgP) for gene-sex interactions. PUBMED: 25256105
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