DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: type II diabetes mellitus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JT Salonen, P Uimari, JM Aalto, M Pirskanen, J Kaikkonen, B Todorova, J Hyppönen, VP Korhonen, J Asikainen, C Devine, TP Tuomainen, J Luedemann, M Nauck, W Kerner, RH Stephens, JP New, WE Ollier, JM Gibson, A Payton, MA Horan, N Pendleton, W Mahoney, D Meyre, J Delplanque, P Froguel, O Luzzatto, B Yakir, A Darvasi

TITLE:

Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.

JOURNAL:

American journal of human genetics Aug 2007, Vol 81, pp. 338-45

ABSTRACT:

Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. PUBMED: 17668382
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