DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Coronary heart disease. The EFO term coronary heart disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coronary heart disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

J Erdmann, A Grosshennig, PS Braund, IR König, C Hengstenberg, AS Hall, P Linsel-Nitschke, S Kathiresan, B Wright, DA Trégouët, F Cambien, P Bruse, Z Aherrahrou, AK Wagner, K Stark, SM Schwartz, V Salomaa, R Elosua, O Melander, BF Voight, CJ O'Donnell, L Peltonen, DS Siscovick, D Altshuler, PA Merlini, F Peyvandi, L Bernardinelli, D Ardissino, A Schillert, S Blankenberg, T Zeller, P Wild, DF Schwarz, L Tiret, C Perret, S Schreiber, NE El Mokhtari, A Schäfer, W März, W Renner, P Bugert, H Klüter, J Schrezenmeir, D Rubin, SG Ball, AJ Balmforth, HE Wichmann, T Meitinger, M Fischer, C Meisinger, J Baumert, A Peters, WH Ouwehand, P Deloukas, JR Thompson, A Ziegler, NJ Samani, H Schunkert

TITLE:

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

JOURNAL:

Nature genetics Mar 2009, Vol 41, pp. 280-2

ABSTRACT:

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11). PUBMED: 19198612
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