DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Eosinophil counts. The EFO term eosinophil count was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: eosinophil count

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DF Gudbjartsson, US Bjornsdottir, E Halapi, A Helgadottir, P Sulem, GM Jonsdottir, G Thorleifsson, H Helgadottir, V Steinthorsdottir, H Stefansson, C Williams, J Hui, J Beilby, NM Warrington, A James, LJ Palmer, GH Koppelman, A Heinzmann, M Krueger, HM Boezen, A Wheatley, J Altmuller, HD Shin, ST Uh, HS Cheong, B Jonsdottir, D Gislason, CS Park, LM Rasmussen, C Porsbjerg, JW Hansen, V Backer, T Werge, C Janson, UB Jönsson, MC Ng, J Chan, WY So, R Ma, SH Shah, CB Granger, AA Quyyumi, AI Levey, V Vaccarino, MP Reilly, DJ Rader, MJ Williams, AM van Rij, GT Jones, E Trabetti, G Malerba, PF Pignatti, A Boner, L Pescollderungg, D Girelli, O Olivieri, N Martinelli, BR Ludviksson, D Ludviksdottir, GI Eyjolfsson, D Arnar, G Thorgeirsson, K Deichmann, PJ Thompson, M Wjst, IP Hall, DS Postma, T Gislason, J Gulcher, A Kong, I Jonsdottir, U Thorsteinsdottir, K Stefansson

TITLE:

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.

JOURNAL:

Nature genetics Mar 2009, Vol 41, pp. 342-7

ABSTRACT:

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls). PUBMED: 19198610
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