DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systolic blood pressure. The EFO term systolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: systolic blood pressure

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

GB Ehret, PB Munroe, KM Rice, M Bochud, AD Johnson, DI Chasman, AV Smith, MD Tobin, GC Verwoert, SJ Hwang, V Pihur, P Vollenweider, PF O'Reilly, N Amin, JL Bragg-Gresham, A Teumer, NL Glazer, L Launer, JH Zhao, Y Aulchenko, S Heath, S Sõber, A Parsa, J Luan, P Arora, A Dehghan, F Zhang, G Lucas, AA Hicks, AU Jackson, JF Peden, T Tanaka, SH Wild, I Rudan, W Igl, Y Milaneschi, AN Parker, C Fava, JC Chambers, ER Fox, M Kumari, MJ Go, P van der Harst, WH Kao, M Sjögren, DG Vinay, M Alexander, Y Tabara, S Shaw-Hawkins, PH Whincup, Y Liu, G Shi, J Kuusisto, B Tayo, M Seielstad, X Sim, KD Nguyen, T Lehtimäki, G Matullo, Y Wu, TR Gaunt, NC Onland-Moret, MN Cooper, CG Platou, E Org, R Hardy, S Dahgam, J Palmen, V Vitart, PS Braund, T Kuznetsova, CS Uiterwaal, A Adeyemo, W Palmas, H Campbell, B Ludwig, M Tomaszewski, I Tzoulaki, ND Palmer, T Aspelund, M Garcia, YP Chang, JR O'Connell, NI Steinle, DE Grobbee, DE Arking, SL Kardia, AC Morrison, D Hernandez, S Najjar, WL McArdle, D Hadley, MJ Brown, JM Connell, AD Hingorani, IN Day, DA Lawlor, JP Beilby, RW Lawrence, R Clarke, JC Hopewell, H Ongen, AW Dreisbach, Y Li, JH Young, JC Bis, M Kähönen, J Viikari, LS Adair, NR Lee, MH Chen, M Olden, C Pattaro, JA Bolton, A Köttgen, S Bergmann, V Mooser, N Chaturvedi, TM Frayling, M Islam, TH Jafar, J Erdmann, SR Kulkarni, SR Bornstein, J Grässler, L Groop, BF Voight, J Kettunen, P Howard, A Taylor, S Guarrera, F Ricceri, V Emilsson, A Plump, I Barroso, KT Khaw, AB Weder, SC Hunt, YV Sun, RN Bergman, FS Collins, LL Bonnycastle, LJ Scott, HM Stringham, L Peltonen, M Perola, E Vartiainen, SM Brand, JA Staessen, TJ Wang, PR Burton, M Soler Artigas, Y Dong, H Snieder, X Wang, H Zhu, KK Lohman, ME Rudock, SR Heckbert, NL Smith, KL Wiggins, A Doumatey, D Shriner, G Veldre, M Viigimaa, S Kinra, D Prabhakaran, V Tripathy, CD Langefeld, A Rosengren, DS Thelle, AM Corsi, A Singleton, T Forrester, G Hilton, CA McKenzie, T Salako, N Iwai, Y Kita, T Ogihara, T Ohkubo, T Okamura, H Ueshima, S Umemura, S Eyheramendy, T Meitinger, HE Wichmann, YS Cho, HL Kim, JY Lee, J Scott, JS Sehmi, W Zhang, B Hedblad, P Nilsson, GD Smith, A Wong, N Narisu, A Stančáková, LJ Raffel, J Yao, S Kathiresan, CJ O'Donnell, SM Schwartz, MA Ikram, WT Longstreth, TH Mosley, S Seshadri, NR Shrine, LV Wain, MA Morken, AJ Swift, J Laitinen, I Prokopenko, P Zitting, JA Cooper, SE Humphries, J Danesh, A Rasheed, A Goel, A Hamsten, H Watkins, SJ Bakker, WH van Gilst, CS Janipalli, KR Mani, CS Yajnik, A Hofman, FU Mattace-Raso, BA Oostra, A Demirkan, A Isaacs, F Rivadeneira, EG Lakatta, M Orru, A Scuteri, M Ala-Korpela, AJ Kangas, LP Lyytikäinen, P Soininen, T Tukiainen, P Würtz, RT Ong, M Dörr, HK Kroemer, U Völker, H Völzke, P Galan, S Hercberg, M Lathrop, D Zelenika, P Deloukas, M Mangino, TD Spector, G Zhai, JF Meschia, MA Nalls, P Sharma, J Terzic, MV Kumar, M Denniff, E Zukowska-Szczechowska, LE Wagenknecht, FG Fowkes, FJ Charchar, PE Schwarz, C Hayward, X Guo, C Rotimi, ML Bots, E Brand, NJ Samani, O Polasek, PJ Talmud, F Nyberg, D Kuh, M Laan, K Hveem, LJ Palmer, YT van der Schouw, JP Casas, KL Mohlke, P Vineis, O Raitakari, SK Ganesh, TY Wong, ES Tai, RS Cooper, M Laakso, DC Rao, TB Harris, RW Morris, AF Dominiczak, M Kivimaki, MG Marmot, T Miki, D Saleheen, GR Chandak, J Coresh, G Navis, V Salomaa, BG Han, X Zhu, JS Kooner, O Melander, PM Ridker, S Bandinelli, UB Gyllensten, AF Wright, JF Wilson, L Ferrucci, M Farrall, J Tuomilehto, PP Pramstaller, R Elosua, N Soranzo, EJ Sijbrands, D Altshuler, RJ Loos, AR Shuldiner, C Gieger, P Meneton, AG Uitterlinden, NJ Wareham, V Gudnason, JI Rotter, R Rettig, M Uda, DP Strachan, JC Witteman, AL Hartikainen, JS Beckmann, E Boerwinkle, RS Vasan, M Boehnke, MG Larson, MR Järvelin, BM Psaty, GR Abecasis, A Chakravarti, P Elliott, CM van Duijn, C Newton-Cheh, D Levy, MJ Caulfield, T Johnson

TITLE:

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

JOURNAL:

Nature Sep 2011, Vol 478, pp. 103-9

ABSTRACT:

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention. PUBMED: 21909115
Find other GeneSets from this publication