DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Alzheimer's disease. The EFO term Alzheimers disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Alzheimers disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, JS Pahwa, V Moskvina, K Dowzell, A Williams, N Jones, C Thomas, A Stretton, AR Morgan, S Lovestone, J Powell, P Proitsi, MK Lupton, C Brayne, DC Rubinsztein, M Gill, B Lawlor, A Lynch, K Morgan, KS Brown, PA Passmore, D Craig, B McGuinness, S Todd, C Holmes, D Mann, AD Smith, S Love, PG Kehoe, J Hardy, S Mead, N Fox, M Rossor, J Collinge, W Maier, F Jessen, B Schürmann, R Heun, H van den Bussche, I Heuser, J Kornhuber, J Wiltfang, M Dichgans, L Frölich, H Hampel, M Hüll, D Rujescu, AM Goate, JS Kauwe, C Cruchaga, P Nowotny, JC Morris, K Mayo, K Sleegers, K Bettens, S Engelborghs, PP De Deyn, C Van Broeckhoven, G Livingston, NJ Bass, H Gurling, A McQuillin, R Gwilliam, P Deloukas, A Al-Chalabi, CE Shaw, M Tsolaki, AB Singleton, R Guerreiro, TW Mühleisen, MM Nöthen, S Moebus, KH Jöckel, N Klopp, HE Wichmann, MM Carrasquillo, VS Pankratz, SG Younkin, PA Holmans, M O'Donovan, MJ Owen, J Williams

TITLE:

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

JOURNAL:

Nature genetics Oct 2009, Vol 41, pp. 1088-93

ABSTRACT:

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 x 10(-157)) and observed genome-wide significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8)). These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). PUBMED: 19734902
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