DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes and other traits. The EFO term type II diabetes mellitus, autoantibody measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: type II diabetes mellitus, autoantibody measurement

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

8

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

J Rung, S Cauchi, A Albrechtsen, L Shen, G Rocheleau, C Cavalcanti-Proença, F Bacot, B Balkau, A Belisle, K Borch-Johnsen, G Charpentier, C Dina, E Durand, P Elliott, S Hadjadj, MR Järvelin, J Laitinen, T Lauritzen, M Marre, A Mazur, D Meyre, A Montpetit, C Pisinger, B Posner, P Poulsen, A Pouta, M Prentki, R Ribel-Madsen, A Ruokonen, A Sandbaek, D Serre, J Tichet, M Vaxillaire, JF Wojtaszewski, A Vaag, T Hansen, C Polychronakos, O Pedersen, P Froguel, R Sladek

TITLE:

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

JOURNAL:

Nature genetics Oct 2009, Vol 41, pp. 1110-5

ABSTRACT:

Genome-wide association studies have identified common variants that only partially explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from 1,376 French individuals, we identified 16,360 SNPs nominally associated with T2D and studied these SNPs in an independent sample of 4,977 French individuals. We then selected the 28 best hits for replication in 7,698 Danish subjects and identified 4 SNPs showing strong association with T2D, one of which (rs2943641, P = 9.3 x 10(-12), OR = 1.19) was located adjacent to the insulin receptor substrate 1 gene (IRS1). Unlike previously reported T2D risk loci, which predominantly associate with impaired beta cell function, the C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies. PUBMED: 19734900
Find other GeneSets from this publication