DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Pulse pressure. The EFO term pulse pressure measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: pulse pressure measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

N Kato, M Loh, F Takeuchi, N Verweij, X Wang, W Zhang, TN Kelly, D Saleheen, B Lehne, I Mateo Leach, AW Drong, J Abbott, S Wahl, ST Tan, WR Scott, G Campanella, M Chadeau-Hyam, U Afzal, TS Ahluwalia, MJ Bonder, P Chen, A Dehghan, TL Edwards, T Esko, MJ Go, SE Harris, J Hartiala, S Kasela, A Kasturiratne, CC Khor, ME Kleber, H Li, ZY Mok, M Nakatochi, NS Sapari, R Saxena, AF Stewart, L Stolk, Y Tabara, AL Teh, Y Wu, JY Wu, Y Zhang, I Aits, A Da Silva Couto Alves, S Das, R Dorajoo, JC Hopewell, YK Kim, RW Koivula, J Luan, LP Lyytikäinen, QN Nguyen, MA Pereira, I Postmus, OT Raitakari, M Scannell Bryan, RA Scott, R Sorice, V Tragante, M Traglia, J White, K Yamamoto, Y Zhang, LS Adair, A Ahmed, K Akiyama, R Asif, T Aung, I Barroso, A Bjonnes, TR Braun, H Cai, LC Chang, CH Chen, CY Cheng, YS Chong, R Collins, R Courtney, G Davies, G Delgado, LD Do, PA Doevendans, RT Gansevoort, YT Gao, TB Grammer, N Grarup, J Grewal, D Gu, GS Wander, AL Hartikainen, SL Hazen, J He, CK Heng, JE Hixson, A Hofman, C Hsu, W Huang, LL Husemoen, JY Hwang, S Ichihara, M Igase, M Isono, JM Justesen, T Katsuya, MG Kibriya, YJ Kim, M Kishimoto, WP Koh, K Kohara, M Kumari, K Kwek, NR Lee, J Lee, J Liao, W Lieb, DC Liewald, T Matsubara, Y Matsushita, T Meitinger, E Mihailov, L Milani, R Mills, N Mononen, M Müller-Nurasyid, T Nabika, E Nakashima, HK Ng, K Nikus, T Nutile, T Ohkubo, K Ohnaka, S Parish, L Paternoster, H Peng, A Peters, ST Pham, MJ Pinidiyapathirage, M Rahman, H Rakugi, O Rolandsson, MA Rozario, D Ruggiero, CF Sala, R Sarju, K Shimokawa, H Snieder, T Sparsø, W Spiering, JM Starr, DJ Stott, DO Stram, T Sugiyama, S Szymczak, WH Tang, L Tong, S Trompet, V Turjanmaa, H Ueshima, AG Uitterlinden, S Umemura, M Vaarasmaki, RM van Dam, WH van Gilst, DJ van Veldhuisen, JS Viikari, M Waldenberger, Y Wang, A Wang, R Wilson, TY Wong, YB Xiang, S Yamaguchi, X Ye, RD Young, TL Young, JM Yuan, X Zhou, FW Asselbergs, M Ciullo, R Clarke, P Deloukas, A Franke, PW Franks, S Franks, Y Friedlander, MD Gross, Z Guo, T Hansen, MR Jarvelin, T Jørgensen, JW Jukema, M Kähönen, H Kajio, M Kivimaki, JY Lee, T Lehtimäki, A Linneberg, T Miki, O Pedersen, NJ Samani, TI Sørensen, R Takayanagi, D Toniolo, H Ahsan, H Allayee, YT Chen, J Danesh, IJ Deary, OH Franco, L Franke, BT Heijman, JD Holbrook, A Isaacs, BJ Kim, X Lin, J Liu, W März, A Metspalu, KL Mohlke, DK Sanghera, XO Shu, JB van Meurs, E Vithana, AR Wickremasinghe, C Wijmenga, BH Wolffenbuttel, M Yokota, W Zheng, D Zhu, P Vineis, SA Kyrtopoulos, JC Kleinjans, MI McCarthy, R Soong, C Gieger, J Scott, YY Teo, J He, P Elliott, ES Tai, P van der Harst, JS Kooner, JC Chambers

TITLE:

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

JOURNAL:

Nature genetics 11 2015, Vol 47, pp. 1282-93

ABSTRACT:

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation. PUBMED: 26390057
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