DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate cancer. The EFO term prostate carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: prostate carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RA Eeles, Z Kote-Jarai, AA Al Olama, GG Giles, M Guy, G Severi, K Muir, JL Hopper, BE Henderson, CA Haiman, J Schleutker, FC Hamdy, DE Neal, JL Donovan, JL Stanford, EA Ostrander, SA Ingles, EM John, SN Thibodeau, D Schaid, JY Park, A Spurdle, J Clements, JL Dickinson, C Maier, W Vogel, T Dörk, TR Rebbeck, KA Cooney, L Cannon-Albright, PO Chappuis, P Hutter, M Zeegers, R Kaneva, HW Zhang, YJ Lu, WD Foulkes, DR English, DA Leongamornlert, M Tymrakiewicz, J Morrison, AT Ardern-Jones, AL Hall, LT O'Brien, RA Wilkinson, EJ Saunders, EC Page, EJ Sawyer, SM Edwards, DP Dearnaley, A Horwich, RA Huddart, VS Khoo, CC Parker, N Van As, CJ Woodhouse, A Thompson, T Christmas, C Ogden, CS Cooper, MC Southey, A Lophatananon, JF Liu, LN Kolonel, L Le Marchand, T Wahlfors, TL Tammela, A Auvinen, SJ Lewis, A Cox, LM FitzGerald, JS Koopmeiners, DM Karyadi, EM Kwon, MC Stern, R Corral, AD Joshi, A Shahabi, SK McDonnell, TA Sellers, J Pow-Sang, S Chambers, J Aitken, RA Gardiner, J Batra, MA Kedda, F Lose, A Polanowski, B Patterson, J Serth, A Meyer, M Luedeke, K Stefflova, AM Ray, EM Lange, J Farnham, H Khan, C Slavov, A Mitkova, G Cao, DF Easton

TITLE:

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

JOURNAL:

Nature genetics Oct 2009, Vol 41, pp. 1116-21

ABSTRACT:

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)). PUBMED: 19767753
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