DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Menarche (age at onset). The EFO term age at menarche was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: age at menarche

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JR Perry, F Day, CE Elks, P Sulem, DJ Thompson, T Ferreira, C He, DI Chasman, T Esko, G Thorleifsson, E Albrecht, WQ Ang, T Corre, DL Cousminer, B Feenstra, N Franceschini, A Ganna, AD Johnson, S Kjellqvist, KL Lunetta, G McMahon, IM Nolte, L Paternoster, E Porcu, AV Smith, L Stolk, A Teumer, N Tšernikova, E Tikkanen, S Ulivi, EK Wagner, N Amin, LJ Bierut, EM Byrne, JJ Hottenga, DL Koller, M Mangino, TH Pers, LM Yerges-Armstrong, J Hua Zhao, IL Andrulis, H Anton-Culver, F Atsma, S Bandinelli, MW Beckmann, J Benitez, C Blomqvist, SE Bojesen, MK Bolla, B Bonanni, H Brauch, H Brenner, JE Buring, J Chang-Claude, S Chanock, J Chen, G Chenevix-Trench, JM Collée, FJ Couch, D Couper, AD Coviello, A Cox, K Czene, AP D'adamo, G Davey Smith, I De Vivo, EW Demerath, J Dennis, P Devilee, AK Dieffenbach, AM Dunning, G Eiriksdottir, JG Eriksson, PA Fasching, L Ferrucci, D Flesch-Janys, H Flyger, T Foroud, L Franke, ME Garcia, M García-Closas, F Geller, EE de Geus, GG Giles, DF Gudbjartsson, V Gudnason, P Guénel, S Guo, P Hall, U Hamann, R Haring, CA Hartman, AC Heath, A Hofman, MJ Hooning, JL Hopper, FB Hu, DJ Hunter, D Karasik, DP Kiel, JA Knight, VM Kosma, Z Kutalik, S Lai, D Lambrechts, A Lindblom, R Mägi, PK Magnusson, A Mannermaa, NG Martin, G Masson, PF McArdle, WL McArdle, M Melbye, K Michailidou, E Mihailov, L Milani, RL Milne, H Nevanlinna, P Neven, EA Nohr, AJ Oldehinkel, BA Oostra, A Palotie, M Peacock, NL Pedersen, P Peterlongo, J Peto, PD Pharoah, DS Postma, A Pouta, K Pylkäs, P Radice, S Ring, F Rivadeneira, A Robino, LM Rose, A Rudolph, V Salomaa, S Sanna, D Schlessinger, MK Schmidt, MC Southey, U Sovio, MJ Stampfer, D Stöckl, AM Storniolo, NJ Timpson, J Tyrer, JA Visser, P Vollenweider, H Völzke, G Waeber, M Waldenberger, H Wallaschofski, Q Wang, G Willemsen, R Winqvist, BH Wolffenbuttel, MJ Wright, DI Boomsma, MJ Econs, KT Khaw, RJ Loos, MI McCarthy, GW Montgomery, JP Rice, EA Streeten, U Thorsteinsdottir, CM van Duijn, BZ Alizadeh, S Bergmann, E Boerwinkle, HA Boyd, L Crisponi, P Gasparini, C Gieger, TB Harris, E Ingelsson, MR Järvelin, P Kraft, D Lawlor, A Metspalu, CE Pennell, PM Ridker, H Snieder, TI Sørensen, TD Spector, DP Strachan, AG Uitterlinden, NJ Wareham, E Widen, M Zygmunt, A Murray, DF Easton, K Stefansson, JM Murabito, KK Ong

TITLE:

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

JOURNAL:

Nature Oct 2014, Vol 514, pp. 92-7

ABSTRACT:

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition. PUBMED: 25231870
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