DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Adiposity. The EFO term obesity was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: obesity

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

CM Lindgren, IM Heid, JC Randall, C Lamina, V Steinthorsdottir, L Qi, EK Speliotes, G Thorleifsson, CJ Willer, BM Herrera, AU Jackson, N Lim, P Scheet, N Soranzo, N Amin, YS Aulchenko, JC Chambers, A Drong, J Luan, HN Lyon, F Rivadeneira, S Sanna, NJ Timpson, MC Zillikens, JH Zhao, P Almgren, S Bandinelli, AJ Bennett, RN Bergman, LL Bonnycastle, SJ Bumpstead, SJ Chanock, L Cherkas, P Chines, L Coin, C Cooper, G Crawford, A Doering, A Dominiczak, AS Doney, S Ebrahim, P Elliott, MR Erdos, K Estrada, L Ferrucci, G Fischer, NG Forouhi, C Gieger, H Grallert, CJ Groves, S Grundy, C Guiducci, D Hadley, A Hamsten, AS Havulinna, A Hofman, R Holle, JW Holloway, T Illig, B Isomaa, LC Jacobs, K Jameson, P Jousilahti, F Karpe, J Kuusisto, J Laitinen, GM Lathrop, DA Lawlor, M Mangino, WL McArdle, T Meitinger, MA Morken, AP Morris, P Munroe, N Narisu, A Nordström, P Nordström, BA Oostra, CN Palmer, F Payne, JF Peden, I Prokopenko, F Renström, A Ruokonen, V Salomaa, MS Sandhu, LJ Scott, A Scuteri, K Silander, K Song, X Yuan, HM Stringham, AJ Swift, T Tuomi, M Uda, P Vollenweider, G Waeber, C Wallace, GB Walters, MN Weedon, JC Witteman, C Zhang, W Zhang, MJ Caulfield, FS Collins, G Davey Smith, IN Day, PW Franks, AT Hattersley, FB Hu, MR Jarvelin, A Kong, JS Kooner, M Laakso, E Lakatta, V Mooser, AD Morris, L Peltonen, NJ Samani, TD Spector, DP Strachan, T Tanaka, J Tuomilehto, AG Uitterlinden, CM van Duijn, NJ Wareham, Hugh Watkins, DM Waterworth, M Boehnke, P Deloukas, L Groop, DJ Hunter, U Thorsteinsdottir, D Schlessinger, HE Wichmann, TM Frayling, GR Abecasis, JN Hirschhorn, RJ Loos, K Stefansson, KL Mohlke, I Barroso, MI McCarthy

TITLE:

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

JOURNAL:

PLoS genetics Jun 2009, Vol 5, pp. e1000508

ABSTRACT:

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity. PUBMED: 19557161
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