DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Abdominal aortic aneurysm. The EFO term Abdominal Aortic Aneurysm was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Abdominal Aortic Aneurysm

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

S Gretarsdottir, AF Baas, G Thorleifsson, H Holm, M den Heijer, JP de Vries, SE Kranendonk, CJ Zeebregts, SM van Sterkenburg, RH Geelkerken, AM van Rij, MJ Williams, AP Boll, JP Kostic, A Jonasdottir, A Jonasdottir, GB Walters, G Masson, P Sulem, J Saemundsdottir, M Mouy, KP Magnusson, G Tromp, JR Elmore, N Sakalihasan, R Limet, JO Defraigne, RE Ferrell, A Ronkainen, YM Ruigrok, C Wijmenga, DE Grobbee, SH Shah, CB Granger, AA Quyyumi, V Vaccarino, RS Patel, AM Zafari, AI Levey, H Austin, D Girelli, PF Pignatti, O Olivieri, N Martinelli, G Malerba, E Trabetti, LC Becker, DM Becker, MP Reilly, DJ Rader, T Mueller, B Dieplinger, M Haltmayer, S Urbonavicius, B Lindblad, A Gottsäter, E Gaetani, R Pola, P Wells, M Rodger, M Forgie, N Langlois, J Corral, V Vicente, J Fontcuberta, F España, N Grarup, T Jørgensen, DR Witte, T Hansen, O Pedersen, KK Aben, J de Graaf, S Holewijn, L Folkersen, A Franco-Cereceda, P Eriksson, DA Collier, H Stefansson, V Steinthorsdottir, T Rafnar, EM Valdimarsson, HB Magnadottir, S Sveinbjornsdottir, I Olafsson, MK Magnusson, R Palmason, V Haraldsdottir, K Andersen, PT Onundarson, G Thorgeirsson, LA Kiemeney, JT Powell, DJ Carey, H Kuivaniemi, JS Lindholt, GT Jones, A Kong, JD Blankensteijn, SE Matthiasson, U Thorsteinsdottir, K Stefansson

TITLE:

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

JOURNAL:

Nature genetics Aug 2010, Vol 42, pp. 692-7

ABSTRACT:

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival. PUBMED: 20622881
Find other GeneSets from this publication