DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

W Wen, W Zheng, Y Okada, F Takeuchi, Y Tabara, JY Hwang, R Dorajoo, H Li, FJ Tsai, X Yang, J He, Y Wu, M He, Y Zhang, J Liang, X Guo, WH Sheu, R Delahanty, X Guo, M Kubo, K Yamamoto, T Ohkubo, MJ Go, JJ Liu, W Gan, CC Chen, Y Gao, S Li, NR Lee, C Wu, X Zhou, H Song, J Yao, IT Lee, J Long, T Tsunoda, K Akiyama, N Takashima, YS Cho, RT Ong, L Lu, CH Chen, A Tan, TK Rice, LS Adair, L Gui, M Allison, WJ Lee, Q Cai, M Isomura, S Umemura, YJ Kim, M Seielstad, J Hixson, YB Xiang, M Isono, BJ Kim, X Sim, W Lu, T Nabika, J Lee, WY Lim, YT Gao, R Takayanagi, DH Kang, TY Wong, CA Hsiung, IC Wu, JM Juang, J Shi, BY Choi, T Aung, F Hu, MK Kim, WY Lim, TD Wang, MH Shin, J Lee, BT Ji, YH Lee, TL Young, DH Shin, BY Chun, MC Cho, BG Han, CM Hwu, TL Assimes, D Absher, X Yan, E Kim, JZ Kuo, S Kwon, KD Taylor, YD Chen, JI Rotter, L Qi, D Zhu, T Wu, KL Mohlke, D Gu, Z Mo, JY Wu, X Lin, T Miki, ES Tai, JY Lee, N Kato, XO Shu, T Tanaka

TITLE:

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

JOURNAL:

Human molecular genetics Oct 2014, Vol 23, pp. 5492-504

ABSTRACT:

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity. PUBMED: 24861553
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