DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Triglycerides. The EFO term triglyceride measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: triglyceride measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

EM van Leeuwen, A Sabo, JC Bis, JE Huffman, A Manichaikul, AV Smith, MF Feitosa, S Demissie, PK Joshi, Q Duan, J Marten, JB van Klinken, I Surakka, IM Nolte, W Zhang, H Mbarek, R Li-Gao, S Trompet, N Verweij, E Evangelou, LP Lyytikäinen, BO Tayo, J Deelen, PJ van der Most, SW van der Laan, DE Arking, A Morrison, A Dehghan, OH Franco, A Hofman, F Rivadeneira, EJ Sijbrands, AG Uitterlinden, JC Mychaleckyj, A Campbell, LJ Hocking, S Padmanabhan, JA Brody, KM Rice, CC White, T Harris, A Isaacs, H Campbell, LA Lange, I Rudan, I Kolcic, P Navarro, T Zemunik, V Salomaa, AS Kooner, JS Kooner, B Lehne, WR Scott, ST Tan, EJ de Geus, Y Milaneschi, BW Penninx, G Willemsen, R de Mutsert, I Ford, RT Gansevoort, MP Segura-Lepe, OT Raitakari, JS Viikari, K Nikus, T Forrester, CA McKenzie, AJ de Craen, HM de Ruijter, G Pasterkamp, H Snieder, AJ Oldehinkel, PE Slagboom, RS Cooper, M Kähönen, T Lehtimäki, P Elliott, P van der Harst, JW Jukema, DO Mook-Kanamori, DI Boomsma, JC Chambers, M Swertz, S Ripatti, K Willems van Dijk, V Vitart, O Polasek, C Hayward, JG Wilson, JF Wilson, V Gudnason, SS Rich, BM Psaty, IB Borecki, E Boerwinkle, JI Rotter, LA Cupples, CM van Duijn

TITLE:

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

JOURNAL:

Journal of medical genetics Jul 2016, Vol 53, pp. 441-9

ABSTRACT:

So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. PUBMED: 27036123
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