DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Brain structure. The EFO term hippocampal volume was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: hippocampal volume

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

3

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

JL Stein, SE Medland, AA Vasquez, DP Hibar, RE Senstad, AM Winkler, R Toro, K Appel, R Bartecek, Ø Bergmann, M Bernard, AA Brown, DM Cannon, MM Chakravarty, A Christoforou, M Domin, O Grimm, M Hollinshead, AJ Holmes, G Homuth, JJ Hottenga, C Langan, LM Lopez, NK Hansell, KS Hwang, S Kim, G Laje, PH Lee, X Liu, E Loth, A Lourdusamy, M Mattingsdal, S Mohnke, SM Maniega, K Nho, AC Nugent, C O'Brien, M Papmeyer, B Pütz, A Ramasamy, J Rasmussen, M Rijpkema, SL Risacher, JC Roddey, EJ Rose, M Ryten, L Shen, E Sprooten, E Strengman, A Teumer, D Trabzuni, J Turner, K van Eijk, TG van Erp, MJ van Tol, K Wittfeld, C Wolf, S Woudstra, A Aleman, S Alhusaini, L Almasy, EB Binder, DG Brohawn, RM Cantor, MA Carless, A Corvin, M Czisch, JE Curran, G Davies, MA de Almeida, N Delanty, C Depondt, R Duggirala, TD Dyer, S Erk, J Fagerness, PT Fox, NB Freimer, M Gill, HH Göring, DJ Hagler, D Hoehn, F Holsboer, M Hoogman, N Hosten, N Jahanshad, MP Johnson, D Kasperaviciute, JW Kent, P Kochunov, JL Lancaster, SM Lawrie, DC Liewald, R Mandl, M Matarin, M Mattheisen, E Meisenzahl, I Melle, EK Moses, TW Mühleisen, M Nauck, MM Nöthen, RL Olvera, M Pandolfo, GB Pike, R Puls, I Reinvang, ME Rentería, M Rietschel, JL Roffman, NA Royle, D Rujescu, J Savitz, HG Schnack, K Schnell, N Seiferth, C Smith, VM Steen, MC Valdés Hernández, M Van den Heuvel, NJ van der Wee, NE Van Haren, JA Veltman, H Völzke, R Walker, LT Westlye, CD Whelan, I Agartz, DI Boomsma, GL Cavalleri, AM Dale, S Djurovic, WC Drevets, P Hagoort, J Hall, A Heinz, CR Jack, TM Foroud, S Le Hellard, F Macciardi, GW Montgomery, JB Poline, DJ Porteous, SM Sisodiya, JM Starr, J Sussmann, AW Toga, DJ Veltman, H Walter, MW Weiner, JC Bis, MA Ikram, AV Smith, V Gudnason, C Tzourio, MW Vernooij, LJ Launer, C DeCarli, S Seshadri, OA Andreassen, LG Apostolova, ME Bastin, J Blangero, HG Brunner, RL Buckner, S Cichon, G Coppola, GI de Zubicaray, IJ Deary, G Donohoe, EJ de Geus, T Espeseth, G Fernández, DC Glahn, HJ Grabe, J Hardy, HE Hulshoff Pol, M Jenkinson, RS Kahn, C McDonald, AM McIntosh, FJ McMahon, KL McMahon, A Meyer-Lindenberg, DW Morris, B Müller-Myhsok, TE Nichols, RA Ophoff, T Paus, Z Pausova, BW Penninx, SG Potkin, PG Sämann, AJ Saykin, G Schumann, JW Smoller, JM Wardlaw, ME Weale, NG Martin, B Franke, MJ Wright, PM Thompson

TITLE:

Identification of common variants associated with human hippocampal and intracranial volumes.

JOURNAL:

Nature genetics Apr 2012, Vol 44, pp. 552-61

ABSTRACT:

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10(-7)). PUBMED: 22504417
Find other GeneSets from this publication