DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was White matter hyperintensity burden. The EFO term white matter hyperintensity measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: white matter hyperintensity measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

BF Verhaaren, S Debette, JC Bis, JA Smith, MK Ikram, HH Adams, AH Beecham, KB Rajan, LM Lopez, S Barral, MA van Buchem, J van der Grond, AV Smith, K Hegenscheid, NT Aggarwal, M de Andrade, EJ Atkinson, M Beekman, AS Beiser, SH Blanton, E Boerwinkle, AM Brickman, RN Bryan, G Chauhan, CP Chen, V Chouraki, AJ de Craen, F Crivello, IJ Deary, J Deelen, PL De Jager, C Dufouil, MS Elkind, DA Evans, P Freudenberger, RF Gottesman, V Guðnason, M Habes, SR Heckbert, G Heiss, S Hilal, E Hofer, A Hofman, CA Ibrahim-Verbaas, DS Knopman, CE Lewis, J Liao, DC Liewald, M Luciano, A van der Lugt, OO Martinez, R Mayeux, B Mazoyer, M Nalls, M Nauck, WJ Niessen, BA Oostra, BM Psaty, KM Rice, JI Rotter, B von Sarnowski, H Schmidt, PJ Schreiner, M Schuur, SS Sidney, S Sigurdsson, PE Slagboom, DJ Stott, JC van Swieten, A Teumer, AM Töglhofer, M Traylor, S Trompet, ST Turner, C Tzourio, HW Uh, AG Uitterlinden, MW Vernooij, JJ Wang, TY Wong, JM Wardlaw, BG Windham, K Wittfeld, C Wolf, CB Wright, Q Yang, W Zhao, A Zijdenbos, JW Jukema, RL Sacco, SL Kardia, P Amouyel, TH Mosley, WT Longstreth, CC DeCarli, CM van Duijn, R Schmidt, LJ Launer, HJ Grabe, SS Seshadri, MA Ikram, M Fornage

TITLE:

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.

JOURNAL:

Circulation. Cardiovascular genetics Apr 2015, Vol 8, pp. 398-409

ABSTRACT:

The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multiethnic genome-wide association studies. PUBMED: 25663218
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