DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RJ Loos, CM Lindgren, S Li, E Wheeler, JH Zhao, I Prokopenko, M Inouye, RM Freathy, AP Attwood, JS Beckmann, SI Berndt, KB Jacobs, SJ Chanock, RB Hayes, S Bergmann, AJ Bennett, SA Bingham, M Bochud, M Brown, S Cauchi, JM Connell, C Cooper, GD Smith, I Day, C Dina, S De, ET Dermitzakis, AS Doney, KS Elliott, P Elliott, DM Evans, I Sadaf Farooqi, P Froguel, J Ghori, CJ Groves, R Gwilliam, D Hadley, AS Hall, AT Hattersley, J Hebebrand, IM Heid, C Lamina, C Gieger, T Illig, T Meitinger, HE Wichmann, B Herrera, A Hinney, SE Hunt, MR Jarvelin, T Johnson, JD Jolley, F Karpe, A Keniry, KT Khaw, RN Luben, M Mangino, J Marchini, WL McArdle, R McGinnis, D Meyre, PB Munroe, AD Morris, AR Ness, MJ Neville, AC Nica, KK Ong, S O'Rahilly, KR Owen, CN Palmer, K Papadakis, S Potter, A Pouta, L Qi, JC Randall, NW Rayner, SM Ring, MS Sandhu, A Scherag, MA Sims, K Song, N Soranzo, EK Speliotes, HE Syddall, SA Teichmann, NJ Timpson, JH Tobias, M Uda, CI Vogel, C Wallace, DM Waterworth, MN Weedon, CJ Willer, Wraight, X Yuan, E Zeggini, JN Hirschhorn, DP Strachan, WH Ouwehand, MJ Caulfield, NJ Samani, TM Frayling, P Vollenweider, G Waeber, V Mooser, P Deloukas, MI McCarthy, NJ Wareham, I Barroso, KB Jacobs, SJ Chanock, RB Hayes, C Lamina, C Gieger, T Illig, T Meitinger, HE Wichmann, P Kraft, SE Hankinson, DJ Hunter, FB Hu, HN Lyon, BF Voight, M Ridderstrale, L Groop, P Scheet, S Sanna, GR Abecasis, G Albai, R Nagaraja, D Schlessinger, AU Jackson, J Tuomilehto, FS Collins, M Boehnke, KL Mohlke

TITLE:

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

JOURNAL:

Nature genetics Jun 2008, Vol 40, pp. 768-75

ABSTRACT:

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2.8 x 10(-15)) and 5,988 children aged 7-11 (0.13 Z-score units; P = 1.5 x 10(-8)). In case-control analyses (n = 10,583), the odds for severe childhood obesity reached 1.30 (P = 8.0 x 10(-11)). Furthermore, we observed overtransmission of the risk allele to obese offspring in 660 families (P (pedigree disequilibrium test average; PDT-avg) = 2.4 x 10(-4)). The SNP location and patterns of phenotypic associations are consistent with effects mediated through altered MC4R function. Our findings establish that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits. PUBMED: 18454148
Find other GeneSets from this publication