DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: type II diabetes mellitus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

R Saxena, BF Voight, V Lyssenko, NP Burtt, PI de Bakker, H Chen, JJ Roix, S Kathiresan, JN Hirschhorn, MJ Daly, TE Hughes, L Groop, D Altshuler, P Almgren, JC Florez, J Meyer, K Ardlie, K Bengtsson Boström, B Isomaa, G Lettre, U Lindblad, HN Lyon, O Melander, C Newton-Cheh, P Nilsson, M Orho-Melander, L Råstam, EK Speliotes, MR Taskinen, T Tuomi, C Guiducci, A Berglund, J Carlson, L Gianniny, R Hackett, L Hall, J Holmkvist, E Laurila, M Sjögren, M Sterner, A Surti, M Svensson, M Svensson, R Tewhey, B Blumenstiel, M Parkin, M Defelice, R Barry, W Brodeur, J Camarata, N Chia, M Fava, J Gibbons, B Handsaker, C Healy, K Nguyen, C Gates, C Sougnez, D Gage, M Nizzari, SB Gabriel, GW Chirn, Q Ma, H Parikh, D Richardson, D Ricke, S Purcell

TITLE:

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

JOURNAL:

Science (New York, N.Y.) Jun 2007, Vol 316, pp. 1331-6

ABSTRACT:

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases. PUBMED: 17463246
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