DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was vWF and FVIII levels. The EFO term factor VIII measurement, coagulation factor measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: factor VIII measurement, coagulation factor measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

G Antoni, T Oudot-Mellakh, A Dimitromanolakis, M Germain, W Cohen, P Wells, M Lathrop, F Gagnon, PE Morange, DA Tregouet

TITLE:

Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.

JOURNAL:

BMC medical genetics Aug 2011, Vol 12, pp. 102

ABSTRACT:

Elevated levels of factor VIII (FVIII) and von Willebrand Factor (vWF) are well-established risk factors for cardiovascular diseases, in particular venous thrombosis. Although high, the heritability of these traits is poorly explained by the genetic factors known so far. The aim of this work was to identify novel single nucleotide polymorphisms (SNPs) that could influence the variability of these traits. PUBMED: 21810271
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