DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Alzheimer's disease (late onset). The EFO term Alzheimers disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Alzheimers disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Miyashita, A Koike, G Jun, LS Wang, S Takahashi, E Matsubara, T Kawarabayashi, M Shoji, N Tomita, H Arai, T Asada, Y Harigaya, M Ikeda, M Amari, H Hanyu, S Higuchi, T Ikeuchi, M Nishizawa, M Suga, Y Kawase, H Akatsu, K Kosaka, T Yamamoto, M Imagawa, T Hamaguchi, M Yamada, T Morihara, T Moriaha, M Takeda, T Takao, K Nakata, Y Fujisawa, K Sasaki, K Watanabe, K Nakashima, K Urakami, T Ooya, M Takahashi, T Yuzuriha, K Serikawa, S Yoshimoto, R Nakagawa, JW Kim, CS Ki, HH Won, DL Na, SW Seo, I Mook-Jung, P St George-Hyslop, R Mayeux, JL Haines, MA Pericak-Vance, M Yoshida, N Nishida, K Tokunaga, K Yamamoto, S Tsuji, I Kanazawa, Y Ihara, GD Schellenberg, LA Farrer, R Kuwano

TITLE:

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.

JOURNAL:

PloS one None 2013, Vol 8, pp. e58618

ABSTRACT:

To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC). In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016). Genome-wide significance was observed with 12 SNPs in the APOE region. Seven SNPs from other distinct regions with p-values <2×10(-5) were genotyped in a second Japanese sample (885 cases, 985 controls), and evidence of association was confirmed for one SORL1 SNP (rs3781834, P = 7.33×10(-7) in the combined sample). Subsequent analysis combining results for several SORL1 SNPs in the Japanese, Korean (339 cases, 1,129 controls) and Caucasians (11,840 AD cases, 10,931 controls) revealed genome wide significance with rs11218343 (P = 1.77×10(-9)) and rs3781834 (P = 1.04×10(-8)). SNPs in previously established AD loci in Caucasians showed strong evidence of association in Japanese including rs3851179 near PICALM (P = 1.71×10(-5)) and rs744373 near BIN1 (P = 1.39×10(-4)). The associated allele for each of these SNPs was the same as in Caucasians. These data demonstrate for the first time genome-wide significance of LOAD with SORL1 and confirm the role of other known loci for LOAD in Japanese. Our study highlights the importance of examining associations in multiple ethnic populations. PUBMED: 23565137
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