DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Leprosy. The EFO term leprosy was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: leprosy

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

H Liu, A Irwanto, X Fu, G Yu, Y Yu, Y Sun, C Wang, Z Wang, Y Okada, H Low, Y Li, H Liany, M Chen, F Bao, J Li, J You, Q Zhang, J Liu, T Chu, AK Andiappan, N Wang, G Niu, D Liu, X Yu, L Zhang, H Tian, G Zhou, O Rotzschke, S Chen, X Zhang, J Liu, F Zhang

TITLE:

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.

JOURNAL:

Nature genetics Mar 2015, Vol 47, pp. 267-71

ABSTRACT:

Genome-wide association studies (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, providing biological insight into the role of host genetic factors in mycobacterial infection. However, the identified loci only partially explain disease heritability, and additional genetic risk factors remain to be discovered. We performed a 3-stage GWAS of leprosy in the Chinese population using 8,313 cases and 16,017 controls. Besides confirming all previously published loci, we discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. A systematic evaluation of pleiotropic effects demonstrated a high tendency for leprosy susceptibility loci to show association with autoimmunity and inflammatory diseases. Further analysis suggests that molecular sensing of infection might have a similar pathogenic role across these diseases, whereas immune responses have discordant roles in infectious and inflammatory diseases. PUBMED: 25642632
Find other GeneSets from this publication