DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: type II diabetes mellitus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

V Steinthorsdottir, G Thorleifsson, I Reynisdottir, R Benediktsson, T Jonsdottir, GB Walters, U Styrkarsdottir, S Gretarsdottir, V Emilsson, S Ghosh, A Baker, S Snorradottir, H Bjarnason, MC Ng, T Hansen, Y Bagger, RL Wilensky, MP Reilly, A Adeyemo, Y Chen, J Zhou, V Gudnason, G Chen, H Huang, K Lashley, A Doumatey, WY So, RC Ma, G Andersen, K Borch-Johnsen, T Jorgensen, JV van Vliet-Ostaptchouk, MH Hofker, C Wijmenga, C Christiansen, DJ Rader, C Rotimi, M Gurney, JC Chan, O Pedersen, G Sigurdsson, JR Gulcher, U Thorsteinsdottir, A Kong, K Stefansson

TITLE:

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.

JOURNAL:

Nature genetics Jun 2007, Vol 39, pp. 770-5

ABSTRACT:

We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk. In addition to confirming two recently identified risk variants, we identified a variant in the CDKAL1 gene that was associated with T2D in individuals of European ancestry (allele-specific odds ratio (OR) = 1.20 (95% confidence interval, 1.13-1.27), P = 7.7 x 10(-9)) and individuals from Hong Kong of Han Chinese ancestry (OR = 1.25 (1.11-1.40), P = 0.00018). The genotype OR of this variant suggested that the effect was substantially stronger in homozygous carriers than in heterozygous carriers. The ORs for homozygotes were 1.50 (1.31-1.72) and 1.55 (1.23-1.95) in the European and Hong Kong groups, respectively. The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion. PUBMED: 17460697
Find other GeneSets from this publication