DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Pancreatic cancer. The EFO term pancreatic carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: pancreatic carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

EJ Childs, E Mocci, D Campa, PM Bracci, S Gallinger, M Goggins, D Li, RE Neale, SH Olson, G Scelo, LT Amundadottir, WR Bamlet, MF Bijlsma, A Blackford, M Borges, P Brennan, H Brenner, HB Bueno-de-Mesquita, F Canzian, G Capurso, GM Cavestro, KG Chaffee, SJ Chanock, SP Cleary, M Cotterchio, L Foretova, C Fuchs, N Funel, M Gazouli, M Hassan, JM Herman, I Holcatova, EA Holly, RN Hoover, RJ Hung, V Janout, TJ Key, J Kupcinskas, RC Kurtz, S Landi, L Lu, E Malecka-Panas, A Mambrini, B Mohelnikova-Duchonova, JP Neoptolemos, AL Oberg, I Orlow, C Pasquali, R Pezzilli, C Rizzato, A Saldia, A Scarpa, RZ Stolzenberg-Solomon, O Strobel, F Tavano, YK Vashist, P Vodicka, BM Wolpin, H Yu, GM Petersen, HA Risch, AP Klein

TITLE:

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

JOURNAL:

Nature genetics Aug 2015, Vol 47, pp. 911-6

ABSTRACT:

Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10(-14)), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10(-8)) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10(-8)). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10(-9)), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk. PUBMED: 26098869
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