DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer (oestrogen-progestogen hormone therapy interaction). The EFO term colorectal cancer, hormone replacement therapy was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: colorectal cancer, hormone replacement therapy

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

X Garcia-Albeniz, A Rudolph, C Hutter, E White, Y Lin, SA Rosse, JC Figueiredo, TA Harrison, S Jiao, H Brenner, G Casey, TJ Hudson, M Thornquist, L Le Marchand, J Potter, ML Slattery, B Zanke, JA Baron, BJ Caan, SJ Chanock, SI Berndt, D Stelling, CS Fuchs, M Hoffmeister, K Butterbach, M Du, W James Gauderman, MJ Gunter, M Lemire, S Ogino, J Lin, RB Hayes, RW Haile, RE Schoen, GS Warnick, MA Jenkins, SN Thibodeau, FR Schumacher, NM Lindor, LN Kolonel, JL Hopper, J Gong, D Seminara, BM Pflugeisen, CM Ulrich, C Qu, D Duggan, M Cotterchio, PT Campbell, CS Carlson, PA Newcomb, E Giovannucci, L Hsu, AT Chan, U Peters, J Chang-Claude

TITLE:

CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk.

JOURNAL:

British journal of cancer Jan 2016, Vol 114, pp. 221-9

ABSTRACT:

Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene-environment interaction analysis to identify genetic modifiers of CRC risk associated with use of MHT. PUBMED: 26766742
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