DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was IgA nephropathy. The EFO term IGA glomerulonephritis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: IGA glomerulonephritis

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

21

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

M Li, JN Foo, JQ Wang, HQ Low, XQ Tang, KY Toh, PR Yin, CC Khor, YF Goh, ID Irwan, RC Xu, AK Andiappan, JX Bei, O Rotzschke, MH Chen, CY Cheng, LD Sun, GR Jiang, TY Wong, HL Lin, T Aung, YH Liao, SM Saw, K Ye, RP Ebstein, QK Chen, W Shi, SH Chew, J Chen, FR Zhang, SP Li, G Xu, ES Tai, L Wang, N Chen, XJ Zhang, YX Zeng, H Zhang, ZH Liu, XQ Yu, JJ Liu

TITLE:

Identification of new susceptibility loci for IgA nephropathy in Han Chinese.

JOURNAL:

Nature communications Jun 2015, Vol 6, pp. 7270

ABSTRACT:

IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptibility loci in Han Chinese, we conduct a four-stage GWAS comprising 8,313 cases and 19,680 controls. Here, we show novel associations at ST6GAL1 on 3q27.3 (rs7634389, odds ratio (OR)=1.13, P=7.27 × 10(-10)), ACCS on 11p11.2 (rs2074038, OR=1.14, P=3.93 × 10(-9)) and ODF1-KLF10 on 8q22.3 (rs2033562, OR=1.13, P=1.41 × 10(-9)), validate a recently reported association at ITGAX-ITGAM on 16p11.2 (rs7190997, OR=1.22, P=2.26 × 10(-19)), and identify three independent signals within the DEFA locus (rs2738058, P=1.15 × 10(-19); rs12716641, P=9.53 × 10(-9); rs9314614, P=4.25 × 10(-9), multivariate association). The risk variants on 3q27.3 and 11p11.2 show strong association with mRNA expression levels in blood cells while allele frequencies of the risk variants within ST6GAL1, ACCS and DEFA correlate with geographical variation in IgAN prevalence. Our findings expand our understanding on IgAN genetic susceptibility and provide novel biological insights into molecular mechanisms underlying IgAN. PUBMED: 26028593
Find other GeneSets from this publication