DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer. The EFO term colorectal cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: colorectal cancer

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

B Zhang, WH Jia, K Matsuda, SS Kweon, K Matsuo, YB Xiang, A Shin, SH Jee, DH Kim, Q Cai, J Long, J Shi, W Wen, G Yang, Y Zhang, C Li, B Li, Y Guo, Z Ren, BT Ji, ZZ Pan, A Takahashi, MH Shin, F Matsuda, YT Gao, JH Oh, S Kim, YO Ahn, AT Chan, J Chang-Claude, ML Slattery, SB Gruber, FR Schumacher, SL Stenzel, G Casey, HR Kim, JY Jeong, JW Park, HL Li, S Hosono, SH Cho, M Kubo, XO Shu, YX Zeng, W Zheng

TITLE:

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

JOURNAL:

Nature genetics Jun 2014, Vol 46, pp. 533-42

ABSTRACT:

Known genetic loci explain only a small proportion of the familial relative risk of colorectal cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with 14,963 cases and 31,945 controls and identified 6 new loci associated with CRC risk (P = 3.42 × 10(-8) to 9.22 × 10(-21)) at 10q22.3, 10q25.2, 11q12.2, 12p13.31, 17p13.3 and 19q13.2. Two of these loci map to genes (TCF7L2 and TGFB1) with established roles in colorectal tumorigenesis. Four other loci are located in or near genes involved in transcriptional regulation (ZMIZ1), genome maintenance (FEN1), fatty acid metabolism (FADS1 and FADS2), cancer cell motility and metastasis (CD9), and cell growth and differentiation (NXN). We also found suggestive evidence for three additional loci associated with CRC risk near genome-wide significance at 8q24.11, 10q21.1 and 10q24.2. Furthermore, we replicated 22 previously reported CRC-associated loci. Our study provides insights into the genetic basis of CRC and suggests the involvement of new biological pathways. PUBMED: 24836286
Find other GeneSets from this publication