DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Hepatocellular carcinoma in hepatitis B infection. The EFO term hepatocellular carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: hepatocellular carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DK Jiang, J Sun, G Cao, Y Liu, D Lin, YZ Gao, WH Ren, XD Long, H Zhang, XP Ma, Z Wang, W Jiang, TY Chen, Y Gao, LD Sun, JR Long, HX Huang, D Wang, H Yu, P Zhang, LS Tang, B Peng, H Cai, TT Liu, P Zhou, F Liu, X Lin, S Tao, B Wan, HX Sai-Yin, LX Qin, J Yin, L Liu, C Wu, Y Pei, YF Zhou, Y Zhai, PX Lu, A Tan, XB Zuo, J Fan, J Chang, X Gu, NJ Wang, Y Li, YK Liu, K Zhai, H Zhang, Z Hu, J Liu, Q Yi, Y Xiang, R Shi, Q Ding, W Zheng, XO Shu, Z Mo, YY Shugart, XJ Zhang, G Zhou, H Shen, SL Zheng, J Xu, L Yu

TITLE:

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.

JOURNAL:

Nature genetics Jan 2013, Vol 45, pp. 72-5

ABSTRACT:

To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases and 4,966 controls). The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49. The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14)). PUBMED: 23242368
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