DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Coronary heart disease. The EFO term coronary heart disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coronary heart disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

PS Wild, T Zeller, A Schillert, S Szymczak, CR Sinning, A Deiseroth, RB Schnabel, E Lubos, T Keller, MS Eleftheriadis, C Bickel, HJ Rupprecht, S Wilde, H Rossmann, P Diemert, LA Cupples, C Perret, J Erdmann, K Stark, ME Kleber, SE Epstein, BF Voight, K Kuulasmaa, M Li, AS Schäfer, N Klopp, PS Braund, HB Sager, S Demissie, C Proust, IR König, HE Wichmann, W Reinhard, MM Hoffmann, J Virtamo, MS Burnett, D Siscovick, PG Wiklund, L Qu, NE El Mokthari, JR Thompson, A Peters, AV Smith, E Yon, J Baumert, C Hengstenberg, W März, P Amouyel, J Devaney, SM Schwartz, O Saarela, NN Mehta, D Rubin, K Silander, AS Hall, J Ferrieres, TB Harris, O Melander, F Kee, H Hakonarson, J Schrezenmeir, V Gudnason, R Elosua, D Arveiler, A Evans, DJ Rader, T Illig, S Schreiber, JC Bis, D Altshuler, M Kavousi, JC Witteman, AG Uitterlinden, A Hofman, AR Folsom, M Barbalic, E Boerwinkle, S Kathiresan, MP Reilly, CJ O'Donnell, NJ Samani, H Schunkert, F Cambien, KJ Lackner, L Tiret, V Salomaa, T Munzel, A Ziegler, S Blankenberg

TITLE:

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.

JOURNAL:

Circulation. Cardiovascular genetics Aug 2011, Vol 4, pp. 403-12

ABSTRACT:

eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). PUBMED: 21606135
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