DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Glomerular filtration rate in chronic kidney disease. The EFO term glomerular filtration rate, chronic kidney disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: glomerular filtration rate, chronic kidney disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M Wuttke, CS Wong, E Wühl, D Epting, L Luo, A Hoppmann, A Doyon, Y Li, B Sözeri, D Thurn, M Helmstädter, TB Huber, TD Blydt-Hansen, A Kramer-Zucker, O Mehls, A Melk, U Querfeld, SL Furth, BA Warady, F Schaefer, A Köttgen

TITLE:

Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.

JOURNAL:

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Feb 2016, Vol 31, pp. 262-9

ABSTRACT:

Chronic kidney disease (CKD) in children is characterized by rapid progression and a high incidence of end-stage renal disease and therefore constitutes an important health problem. While unbiased genetic screens have identified common risk variants influencing renal function and CKD in adults, the presence and identity of such variants in pediatric CKD are unknown. PUBMED: 26420894
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