DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body fat percentage. The EFO term body fat percentage was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body fat percentage

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Y Lu, FR Day, S Gustafsson, ML Buchkovich, J Na, V Bataille, DL Cousminer, Z Dastani, AW Drong, T Esko, DM Evans, M Falchi, MF Feitosa, T Ferreira, ÅK Hedman, R Haring, PG Hysi, MM Iles, AE Justice, S Kanoni, V Lagou, R Li, X Li, A Locke, C Lu, R Mägi, JR Perry, TH Pers, Q Qi, M Sanna, EM Schmidt, WR Scott, D Shungin, A Teumer, AA Vinkhuyzen, RW Walker, HJ Westra, M Zhang, W Zhang, JH Zhao, Z Zhu, U Afzal, TS Ahluwalia, SJ Bakker, C Bellis, A Bonnefond, K Borodulin, AS Buchman, T Cederholm, AC Choh, HJ Choi, JE Curran, LC de Groot, PL De Jager, RA Dhonukshe-Rutten, AW Enneman, E Eury, DS Evans, T Forsen, N Friedrich, F Fumeron, ME Garcia, S Gärtner, BG Han, AS Havulinna, C Hayward, D Hernandez, H Hillege, T Ittermann, JW Kent, I Kolcic, T Laatikainen, J Lahti, I Mateo Leach, CG Lee, JY Lee, T Liu, Y Liu, S Lobbens, M Loh, LP Lyytikäinen, C Medina-Gomez, K Michaëlsson, MA Nalls, CM Nielson, L Oozageer, L Pascoe, L Paternoster, O Polašek, S Ripatti, MA Sarzynski, CS Shin, NS Narančić, D Spira, P Srikanth, E Steinhagen-Thiessen, YJ Sung, KM Swart, L Taittonen, T Tanaka, E Tikkanen, N van der Velde, NM van Schoor, N Verweij, AF Wright, L Yu, JM Zmuda, N Eklund, T Forrester, N Grarup, AU Jackson, K Kristiansson, T Kuulasmaa, J Kuusisto, P Lichtner, J Luan, A Mahajan, S Männistö, CD Palmer, JS Ried, RA Scott, A Stancáková, PJ Wagner, A Demirkan, A Döring, V Gudnason, DP Kiel, B Kühnel, M Mangino, B Mcknight, C Menni, JR O'Connell, BA Oostra, AR Shuldiner, K Song, L Vandenput, CM van Duijn, P Vollenweider, CC White, M Boehnke, Y Boettcher, RS Cooper, NG Forouhi, C Gieger, H Grallert, A Hingorani, T Jørgensen, P Jousilahti, M Kivimaki, M Kumari, M Laakso, C Langenberg, A Linneberg, A Luke, CA Mckenzie, A Palotie, O Pedersen, A Peters, K Strauch, BO Tayo, NJ Wareham, DA Bennett, L Bertram, J Blangero, M Blüher, C Bouchard, H Campbell, NH Cho, SR Cummings, SA Czerwinski, I Demuth, R Eckardt, JG Eriksson, L Ferrucci, OH Franco, P Froguel, RT Gansevoort, T Hansen, TB Harris, N Hastie, M Heliövaara, A Hofman, JM Jordan, A Jula, M Kähönen, E Kajantie, PB Knekt, S Koskinen, P Kovacs, T Lehtimäki, L Lind, Y Liu, ES Orwoll, C Osmond, M Perola, L Pérusse, OT Raitakari, T Rankinen, DC Rao, TK Rice, F Rivadeneira, I Rudan, V Salomaa, TI Sørensen, M Stumvoll, A Tönjes, B Towne, GJ Tranah, A Tremblay, AG Uitterlinden, P van der Harst, E Vartiainen, JS Viikari, V Vitart, MC Vohl, H Völzke, M Walker, H Wallaschofski, S Wild, JF Wilson, L Yengo, DT Bishop, IB Borecki, JC Chambers, LA Cupples, A Dehghan, P Deloukas, G Fatemifar, C Fox, TS Furey, L Franke, J Han, DJ Hunter, J Karjalainen, F Karpe, RC Kaplan, JS Kooner, MI McCarthy, JM Murabito, AP Morris, JA Bishop, KE North, C Ohlsson, KK Ong, I Prokopenko, JB Richards, EE Schadt, TD Spector, E Widén, CJ Willer, J Yang, E Ingelsson, KL Mohlke, JN Hirschhorn, JA Pospisilik, MC Zillikens, C Lindgren, TO Kilpeläinen, RJ Loos

TITLE:

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

JOURNAL:

Nature communications Feb 2016, Vol 7, pp. 10495

ABSTRACT:

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. PUBMED: 26833246
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