DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Blood pressure. The EFO term diastolic blood pressure was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: diastolic blood pressure

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

N Kato, F Takeuchi, Y Tabara, TN Kelly, MJ Go, X Sim, WT Tay, CH Chen, Y Zhang, K Yamamoto, T Katsuya, M Yokota, YJ Kim, RT Ong, T Nabika, D Gu, LC Chang, Y Kokubo, W Huang, K Ohnaka, Y Yamori, E Nakashima, CE Jaquish, JY Lee, M Seielstad, M Isono, JE Hixson, YT Chen, T Miki, X Zhou, T Sugiyama, JP Jeon, JJ Liu, R Takayanagi, SS Kim, T Aung, YJ Sung, X Zhang, TY Wong, BG Han, S Kobayashi, T Ogihara, D Zhu, N Iwai, JY Wu, YY Teo, ES Tai, YS Cho, J He

TITLE:

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

JOURNAL:

Nature genetics Jun 2011, Vol 43, pp. 531-8

ABSTRACT:

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention. PUBMED: 21572416
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