DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

KL Monda, GK Chen, KC Taylor, C Palmer, TL Edwards, LA Lange, MC Ng, AA Adeyemo, MA Allison, LF Bielak, G Chen, M Graff, MR Irvin, SK Rhie, G Li, Y Liu, Y Liu, Y Lu, MA Nalls, YV Sun, MK Wojczynski, LR Yanek, MC Aldrich, A Ademola, CI Amos, EV Bandera, CH Bock, A Britton, U Broeckel, Q Cai, NE Caporaso, CS Carlson, J Carpten, G Casey, WM Chen, F Chen, YD Chen, CW Chiang, GA Coetzee, E Demerath, SL Deming-Halverson, RW Driver, P Dubbert, MF Feitosa, Y Feng, BI Freedman, EM Gillanders, O Gottesman, X Guo, T Haritunians, T Harris, CC Harris, AJ Hennis, DG Hernandez, LH McNeill, TD Howard, BV Howard, VJ Howard, KC Johnson, SJ Kang, BJ Keating, S Kolb, LH Kuller, A Kutlar, CD Langefeld, G Lettre, K Lohman, V Lotay, H Lyon, JE Manson, W Maixner, YA Meng, KR Monroe, I Morhason-Bello, AB Murphy, JC Mychaleckyj, R Nadukuru, KL Nathanson, U Nayak, A N'diaye, B Nemesure, SY Wu, MC Leske, C Neslund-Dudas, M Neuhouser, S Nyante, H Ochs-Balcom, A Ogunniyi, TO Ogundiran, O Ojengbede, OI Olopade, JR Palmer, EA Ruiz-Narvaez, ND Palmer, MF Press, E Rampersaud, LJ Rasmussen-Torvik, JL Rodriguez-Gil, B Salako, EE Schadt, AG Schwartz, DA Shriner, D Siscovick, SB Smith, S Wassertheil-Smoller, EK Speliotes, MR Spitz, L Sucheston, H Taylor, BO Tayo, MA Tucker, DJ Van Den Berg, DR Edwards, Z Wang, JK Wiencke, TW Winkler, JS Witte, M Wrensch, X Wu, JJ Yang, AM Levin, TR Young, NA Zakai, M Cushman, KA Zanetti, JH Zhao, W Zhao, Y Zheng, J Zhou, RG Ziegler, JM Zmuda, JK Fernandes, GS Gilkeson, DL Kamen, KJ Hunt, IJ Spruill, CB Ambrosone, S Ambs, DK Arnett, L Atwood, DM Becker, SI Berndt, L Bernstein, WJ Blot, IB Borecki, EP Bottinger, DW Bowden, G Burke, SJ Chanock, RS Cooper, J Ding, D Duggan, MK Evans, C Fox, WT Garvey, JP Bradfield, H Hakonarson, SF Grant, A Hsing, L Chu, JJ Hu, D Huo, SA Ingles, EM John, JM Jordan, EK Kabagambe, SL Kardia, RA Kittles, PJ Goodman, EA Klein, LN Kolonel, L Le Marchand, S Liu, B McKnight, RC Millikan, TH Mosley, B Padhukasahasram, LK Williams, SR Patel, U Peters, CA Pettaway, PA Peyser, BM Psaty, S Redline, CN Rotimi, BA Rybicki, MM Sale, PJ Schreiner, LB Signorello, AB Singleton, JL Stanford, SS Strom, MJ Thun, M Vitolins, W Zheng, JH Moore, SM Williams, S Ketkar, X Zhu, AB Zonderman, C Kooperberg, GJ Papanicolaou, BE Henderson, AP Reiner, JN Hirschhorn, RJ Loos, KE North, CA Haiman

TITLE:

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

JOURNAL:

Nature genetics Jun 2013, Vol 45, pp. 690-6

ABSTRACT:

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. PUBMED: 23583978
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